This topic from Long and Short Reviews was an interesting one. For one thing, when I need a pick-me-up, I don't tend to turn to a book. I don't know why - I think it's just the immediacy of a film that does it. And my favourite film, funnily enough, is not one that people are likely to think of for a pick-me-up.
I know a lot of people would look at that film and think "How on earth could a film with an ending like that be enjoyable?" And I would agree, except that the rest of the film is both passionate and uplifting. Peter Jackson's direction takes you through a wild swirl of romance and excitement which sweeps you up, all the more to shock you at the end - by which point I'm in a better mood and more ready for it.
My other two go-to films are Blazing Saddles and Willy Wonka and the Chocolate Factory. I absolutely adore Gene Wilder and he is at his hysterical best in these two films, especially Blazing Saddles which is one of the few comedies I actually like. Even though I've seen them both dozens of times I don't miss a moment whenever I watch them.
So what do you go to for a pick-me-up?